Pasteur International Center for Research on Emerging Infectious Diseases
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Surveillance of two arboviruses – Rift Valley Fever and Crimean Congo Hemorrhagic Fever viruses – and yet unknown viruses in high risk populations in Senegal (ARBOSEN)

Rift Valley Fever Virus
Crimean Congo Hemorrhagic Fever Virus


We will identify factors influencing emergence and transmission of RVF and CCHF viruses as well as potential yet unknown arthropod-borne viruses at the virus, vector and reservoir levels, leading to epidemics in suspected spillover conditions.


The specific results expected for IP Dakar are: 1) Strengthen surveillance and detect known or unknown viruses that can spread to humans. We will build on the sentinel syndromic surveillance sites already existing in Senegal and use standard detection and high-throughput sequencing tools (MiSeq, MinION platform) for rapid identification of pathogens in the field. We will also - Analyse the genetic variability of circulating viruses. - Develop new diagnostic tools for detected viruses 2) Understand the dynamics of transmission of endemic RNA viruses at high risk of epidemics. By focusing on the RVF and CCHF viruses, we will be carrying out studies in Senegal on healthy humans using standard and innovative tests in the field. Our objective is to obtain better knowledge of the prevalence and the dynamics of transmission and to identify the main vector insects and animal reservoirs of these viruses. We will also develop a network within the West African region to strengthen capacities for RVFV and CCHFV surveillance and research.

Research reported in this project was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number U01AI151758.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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